Hydrogel dressings loaded with anticancer/antimicrobial Ag(I) camphorimine complexes for treatment of malignant wounds

The treatment of skin wounds caused by metastatic lesions is often difficult because not many medicines exist that simultaneously act on cancer cells and bacteria. In the framework of a multidisciplinary collaborative research, Prof. Jorge H. Leitão and the PhD student Jeremias Muazeia participated a study, recently published in International Journal of Pharmaceutics, on the antimicrobial and anti-cancer activity of a silver camphorimine complex incorporated in a HEMA-based hydrogel to be used as a dressing for skin cancer wounds. The hydrogel disks loaded with the complex effectively reduced suspensions of E. coli, P. aeruginosa and B. contaminans from the initial 5 × 105 CFU/mL to 0 CFU/mL after 24 and 48 h of incubation. In the case of S. aureus, a reduction of more than 99 % was observed after 24 h. However, after 48 h of incubation, the hydrogel was ineffective towards S. aureus. Further in vivo studies are needed to confirm the clinical potential of the dressings. Nevertheless, the produced dressings offer a promising approach for both infection control and cancer therapy in chronic wounds. See more.