As part of the European project UROPRINT , iBB researchers Teresa Mendes, Catarina Carreira, Ana Fernandes Platzgummer, and Cláudia Lobato da Silva recently reported the establishment of a xeno(geneic)-free culture platform for smooth muscle cells envisioning bladder tissue engineering strategies. 

This study establishes a scalable and clinically relevant manufacturing process, from isolation to expansion, using gamma-irradiated human platelet lysate as a xeno-free culture medium supplement. The team successfully confirmed the smooth muscle-like phenotype of the expanded cells and implemented a plastic microcarrier-based spinner flask system, enabling large-scale cell production for future therapeutic applications.

This research paves the way for more efficient and clinically viable strategies in regenerative medicine, bringing us closer to advanced bladder tissue engineering solutions. See more.

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