In recent years, the rise of data collection systems featuring physiological sensors has enabled the creation of vast datasets for various biomedical uses, enhancing wellness and quality of life applications. However, data is often available in raw form and noisy, demanding extensive pre-processing to be application-ready. To facilitate such tasks we introduce BioSPPy, a comprehensive open-source Python toolbox designed to facilitate end-to-end physiological data processing, aggregating functions ranging from data loading, to noise filtering and feature extraction. With a user-friendly semantic keyword-based input/output system, it is tailored for all Python expertise levels. See more.