Mechanochemical inverse vulcanization

Prof. Vasco Bonifácio (DBE, iBB) developed a iron-free mechanochemical inverse vulcanization. This solvent-free reaction, in addition to its importance in a circular economy approach, uses industrial waste to produce chiral oligosulfides, a class of compounds that have therapeutic potential for the treatment of colorectal cancer. The reaction mechanism is proposed, and the formation of the products may follow a homolytic opening of the sulfur ring (S8), triggered by mechanical stress. The formation of thiiranes, sulfur-containing three-membered rings, using mechanosynthesis is reported for the first time. The work was published in RSC Mechanoschemistry, a new journal from the Royal Society of Chemistry, fully dedicated to the field of mechanochemistry. See more.