We are pleased to share our latest contribution to Drug Discovery Stories: From Bench to Bedside with the chapter titled "Unravelling the Drying Techniques of Protein Biopharmaceuticals." Authored by Sofia O.D. Duarte, Adorino Mendonça, Mónica Condinho, and Pedro Fonte, this chapter offers a detailed look at the critical role of drying techniques in ensuring the stability, efficacy, and longevity of protein-based biopharmaceuticals. This chapter reflects the group's expertise in drying techniques for pharmaceutical products and biopharmaceutical delivery.

Protein biopharmaceuticals hold transformative potential in medical treatments, providing high target specificity and low immunogenicity, thereby enhancing therapeutic efficacy and safety. However, maintaining stability in these formulations is challenging due to their sensitivity in aqueous solutions. Techniques such as spray drying and lyophilization are pivotal in converting these formulations into solid forms, thus extending shelf life, preserving bioactivity, and reducing degradation risks. This transition also facilitates alternative administration routes, including inhalable powders and injectable reconstitutable formulations, improving patient compliance and broadening treatment possibilities.

Moreover, large-scale drying methods ensure consistent quality, minimizing batch variability and supporting reliable clinical outcomes. This chapter emphasizes the role of optimized drying processes as an integral part of biopharmaceutical production, contributing to safe, stable, and effective treatments. See more.