ScientISST is a pedagogical innovation project that gathers a team of students and researchers around the common goal of developing biomedical innovations of practical utility. Biomedical instrumentation and signal acquisition is increasingly more pervasive, however, there are multiple hindering factors still conditioning research and development on beyond state-of-the-art solutions. In particular, existing approaches are bound by vendor-imposed restrictions, high costs, and limited options for customization and rapid prototyping. Popular open hardware platforms, which are often seen as an alternative, exhibit performance limitations (https://www.mdpi.com/2624-6120/1/2/6). Through the creation of purpose-built hardware, software, and educational materials, ScientISST greatly accelerates scientific developments in biomedical instrumentation and signal acquisition, enabling anyone, from students to professionals, to bring their biosignal-powered ideas into fruition. See more.