This book introduces common concepts in biosignal acquisition and processing using a Project-Based Learning (PBL). Exercises and corresponding solutions are provided, emphasizing problems that new entrants encounter in the undergraduate and graduate curriculums in biomedical engineering and related areas. Activities encompass sensor design, biosignals acquisition using the Arduino and BITalino platforms, Python for signal processing, analysis, and knowledge extraction. Content is supported with graphics, source code, and other useful resources made available to the interested reader. It is an ideal resource for undergraduate students and practitioners studying or working in the field of biomedical signal acquisition, processing, and analysis. See more.