Prof. Vasco Bonifácio (DBE, iBB) and collaborators from FCT-NOVA University of Lisbon report in Biosensors & Bioelectronics X a fully green process merging mechanosynthesis with supercritical CO₂ template removal. This methodology yields ready-to-use dry powders of beryllium-based molecularly imprinted polymers (BeMIPMs), wherein natural curcumin and lawsone monomers coordinate with Be²⁺ ions to create highly specific binding sites for L-leucine. Via micro-contact deposition onto a thermally conductive layer, these BeMIPMs operate as heat-transfer method (HTM) sensors, exhibiting a detection limit of 0.16 mM for L-leucine. They maintain high selectivity in complex amino acid/BSA mixtures and demonstrate stable performance over repeated sensing cycles. By coupling sustainable production techniques with metal-assisted molecular imprinting, BeMIPMs establish cost-effective, high-precision platforms for amino acid monitoring and purification in biotechnological and biopharmaceutical processes. See more.