SWEET-GOLD: An educational project integrating bioengineering and nanotechnology

The SWEET-GOLD project, proposed by Prof. Ângela Taipa (DBE, iBB), was among the winners of the 2025 edition of the Pedagogical Innovation Projects (PIP). SWEET-GOLD aims for a unique integration of classical bioprocesses (enzymatic catalysis, cell immobilization, modeling, and reactor operation) with advanced molecular detection technologies using nanomaterials. The project is modular and engages students in three key subjects: i) 3D printing (bioreactor and optical reading module of the project), ii) enzymatic catalysis (immobilization of Saccharomyces bayanus invertase enzyme in calcium alginate beads and operation of the enzymatic reactor), and iii) synthesis of optical nanosensors (use of gold nanorods to monitor the enzymatic conversion of sucrose into glucose and fructose using UV-Vis absorption). Prof. Vasco Bonifácio (DBE, iBB) is also part of the project team, contributing to the 3D printing of the bioreactors and the synthesis of the gold nanorods.