Neophaeotheca triangularis as a source of melanin

Gastrointestinal cancers remain one of the leading causes of cancer-related morbidity and mortality, and current treatments are not sufficient to curb their impact. In a recently published paper, Ricardo F.S. Pereira and Carla C.C.R. de Carvalho (2BRG-iBB) in collaboration with researchers from the Universidad de Granada, reviewed systematically studies published during 2015-2025 on bacterial pigments with anticancer potential. Prodigiosin emerged as the most studied pigment, followed by phycocyanin and violacein, particularly against colorectal and liver cancers. The mechanisms of action responsible for the antiproliferative activity of bacterial pigments included cell cycle arrest, apoptosis induction, autophagy modulation, and oxidative stress. See more.
